For Harry Fluder, life was working out exactly how he thought it was supposed to. He had a great job, loyal friends, and the perfect fiancee. However, finding one of his maybe not-so-loyal friends doing a "great job" with his perfect fiancee, was not part of the plan. After cancelling the wedding, Harry, in a drunken stupor, ponders how everything that was so right could have gone so wrong, meanwhile Bowie, Harry's best man, gets a flash of inspiration. Instead of also cancelling the amazing tropical honeymoon, why don't the two of them go instead, on an epic "homie-moon." What is supposed to be a refreshing weekend of rest and relaxation turns into an all-out bonkers adventure of epic proportions. Harry and Bowie will have the time of their lives, if they can just survive this Random Tropical Paradise.

Serial commitment-phobe, Dave, is reeling from his decision to break up with his near perfect, now ex-girlfriend. As he tries to forget her, his battling inner voices come to life and cloud his mind with conflicting desires. Meanwhile, Carrie's own disjointed inner voices push her to move on with someone less complicated. Sensing time is short, Dave embarks on a sincere and sometimes fumbled personal journey to conquer his fear of commitment.

In Bellwood, a mysterious figure teleports into town, and immediately starts destroying things. Ben Tennyson, in the form of Heatblast, confronts him. After a short battle, Ben seemingly obliterates the villain. Max Tennyson identifies him as Eon, an alien the Plumbers captured almost two centuries ago. When he arrived, he was half dead and brought a device with him called the Hands of Armageddon, which would open a time rift to the alien's home dimension and unleash his race upon Earth if activated. They travel to the containment facility where Eon is supposed to be kept, only to find it empty and his guardian aged to near-death.

Jessica Olsen goes to Los Angeles with nothing more in mind that visiting her grandparents while her sister tries to meet Christopher Wilde. One night she meets Christopher Wilde. They go an an adventure around Los Angeles and start to like each other. When Jessica returns home, Christopher, on national TV, says he doesn't know her, and never met her.

Homeless veteran Bob 'Drillbit' Taylor manages to enjoy life anyhow and even saves some cash for his dream, an 'all-paid' move to Alaska, even if that may take many years. His dream comes within reach when clever nerd Wade, has fat friend Ryan 'T-dog' and cocky shrimp Jim, all new to junior high-school, are bullied so badly by emancipated Filkins and his buddies that they advertise for a bodyguard. Only Drillbit seems affordable and not crazy, so he's hired and drains their pocket-money and home content. He's clueless how to protect them but gives them (bogus) self-defense classes.